Be part of the solution! By joining together, we can speed progress toward better treatments and a cure. Below are the current studies underway at the UW Medicine Diabetes Institute Clinical Research Unit.
WEBS: Weight Effects on Brain Health Study
This study seeks to achieve a better understanding of the role of the brain in successful obesity treatment (surgical and lifestyle). PI: Ellen Schur, MD, MS
Brain Effects on Appetite and Metabolism Study This study examines if structural brain changes related to obesity play a role in the central regulation of appetite and weight gain in children. PI: Ellen Schur, MD, MS
Currently EnrollingLipid MRI Study: APOE Genotype Effects on Triglycerides and Blood Flow in the Human Brain
The purpose of this study is to enroll older adults to assess whether the E4 status affects change in global cerebral blood flow in response to a high fat drink. PI: Angela Hanson, MD
Currently EnrollingADT Study: Effect of Androgen Deprivation Therapy on Hypothalamic Gliosis in Men
The purpose of this study is to better understand why androgen deprivation therapy (ADT) increases risk of body weight gain, insulin resistance, and type 2 diabetes in men with prostate cancer. PI: Katya Rubinow, MD
Coming SoonThe Insulin-Only Bionic Pancreas Pivotal Trial
This randomized control trial will compare efficacy and safety endpoints using the insulin-only configuration of the iLet Bionic Pancreas System versus Usual Care during a 13-week study period. PI: Irl Hirsch, MD
Currently EnrollingDERMIS: Defining, Reviewing, and Monitoring Skin Pathologies in T1D
This is an observatory study for people with type 1 diabetes mellitus who are using an insulin pump. DERMIS is an investigational study looking to answer the questions of why pump wearers’ skin changes after a number of years. PI: Irl Hirsch, MD
Coming SoonEvaluating the Safety and Effectiveness of the Omnipod Horizon Automated Glucose Control System in Patients with Type 1 Diabetes
This study aims to evaluate the safety and effectiveness of the Omnipod Horizon Automated Glucose Control System. PI: Irl Hirsch, MD
Currently EnrollingA Study on the Use of Real-Time Continuous Glucose Monitoring in Gestational Diabetes
The purpose of this study is to examine whether real-time continuous glucose monitoring improves glucose control, maternal outcomes, and fetal outcomes in patients diagnosed with gestational diabetes. PI: Nicole Ehrhardt, MD
Currently EnrollingHDL Structure, Function and Glycemic Control in Diabetes
This study aims to learn about the differences in the structure of human lipoproteins (molecules in blood that transport fatty substances through the body) in people with and without diabetes and how these differences are related to blood sugar control. PI: Yi He, PhD & Irl Hirsch, MD
Coming SoonAssociation between Retinal Angiography Findings and Kidney Histopathology in Participants with Diabetes
The purpose of this study is to learn about the relationship between eye disease and kidney disease in people with diabetes. The study aims to identify features of eye health that relate to how diabetes is affecting the kidney. PI: Christine Limonte, MD and Ian de Boer, MD MS
Coming SoonGliding Study
The main purpose of this study is to see if the participants switching with a bridging dose of insulin glargine to insulin degludec have less low blood sugars and better blood sugar control vs those who switch with no bridging dose. PI: Arthi Thirumalai, MBBS, Jing Chao, MD, Irl Hirsch, MD
Currently EnrollingCompleted Studies
BIGR: Brain Inflammation and Glucose Regulation The purpose of this study is to learn more about the differences in brain structure in people with and without Type 2 Diabetes and if these differences impact regulation of blood sugar over time. PI: Ellen Schur, MD, MS
Enrollment CompleteONSET -9 Study
This study is to compare how well 2 medicines work and how safe they are in people with type 2 diabetes: 1) fast-acting insulin aspart (a new medicine) and 2) NovoLog® (a medicine doctors can already prescribe). PI: Subbulaxmi Trikudanathan, MD
Enrollment CompleteMedtronic Closed Loop Study
The purpose of this study is to evaluate the safety and effectiveness of the Hybrid Closed Loop system (HCL), which is built into the 670G insulin pump, in adult and pediatric patients with type 1 diabetes in a home setting. PI: Irl Hirsch, MD
Enrollment CompleteSOTA-CKD3 Study
The primary purpose of this study is to determine whether sotagliflozin taken orally once daily lowers hemoglobin A1C better than for the treatment of Type 2 diabetes in patients with moderate kidney problems. PI: Subbulaxmi Trikudanathan, MD
Enrollment Complete