Clinical Research Unit Current Studies

WEBS: Weight Effects on Brain Health Study
This study seeks to achieve a better understanding of the role of the brain in successful obesity treatment (surgical and lifestyle). PI: Ellen Schur, MD, MS

Brain Effects on Appetite and Metabolism Study
This study examines if structural brain changes related to obesity play a role in the central regulation of appetite and weight gain in children. PI: Ellen Schur, MD, MS

The purpose of this study is to enroll older adults to assess whether the E4 status affects change in global cerebral blood flow in response to a high fat drink. PI: Angela Hanson, MD

The purpose of this study is to better understand why androgen deprivation therapy (ADT) increases risk of body weight gain, insulin resistance, and type 2 diabetes in men with prostate cancer. PI: Katya Rubinow, MD

This randomized control trial will compare efficacy and safety endpoints using the insulin-only configuration of the iLet Bionic Pancreas System versus Usual Care during a 13-week study period. PI: Irl Hirsch, MD

This is an observatory study for people with type 1 diabetes mellitus who are using an insulin pump. DERMIS is an investigational study looking to answer the questions of why pump wearers’ skin changes after a number of years. PI: Irl Hirsch, MD

This study aims to evaluate the safety and effectiveness of the Omnipod Horizon Automated Glucose Control System. PI: Irl Hirsch, MD

The purpose of this study is to examine whether real-time continuous glucose monitoring improves glucose control, maternal outcomes, and fetal outcomes in patients diagnosed with gestational diabetes. PI: Nicole Ehrhardt, MD

This study aims to learn about the differences in the structure of human lipoproteins (molecules in blood that transport fatty substances through the body) in people with and without diabetes and how these differences are related to blood sugar control. PI: Yi He, PhD & Irl Hirsch, MD

The purpose of this study is to learn about the relationship between eye disease and kidney disease in people with diabetes. The study aims to identify features of eye health that relate to how diabetes is affecting the kidney. PI: Christine Limonte, MD and Ian de Boer, MD MS

The main purpose of this study is to see if the participants switching with a bridging dose of insulin glargine to insulin degludec have less low blood sugars and better blood sugar control vs those who switch with no bridging dose. PI: Arthi Thirumalai, MBBS, Jing Chao, MD, Irl Hirsch, MD

BIGR: Brain Inflammation and Glucose Regulation The purpose of this study is to learn more about the differences in brain structure in people with and without Type 2 Diabetes and if these differences impact regulation of blood sugar over time. PI: Ellen Schur, MD, MS

This study is to compare how well 2 medicines work and how safe they are in people with type 2 diabetes: 1) fast-acting insulin aspart (a new medicine) and 2) NovoLog® (a medicine doctors can already prescribe). PI: Subbulaxmi Trikudanathan, MD

The purpose of this study is to evaluate the safety and effectiveness of the Hybrid Closed Loop system (HCL), which is built into the 670G insulin pump, in adult and pediatric patients with type 1 diabetes in a home setting. PI: Irl Hirsch, MD

The primary purpose of this study is to determine whether sotagliflozin taken orally once daily lowers hemoglobin A1C better than for the treatment of Type 2 diabetes in patients with moderate kidney problems. PI: Subbulaxmi Trikudanathan, MD