Clinical Research Unit Current Studies

Be part of the solution! By joining together, we can speed progress toward better treatments and a cure. Below are the current studies underway at the UW Medicine Diabetes Institute Clinical Research Unit.

 

 

WEBS: Weight Effects on Brain Health Study
This study seeks to achieve a better understanding of the role of the brain in successful obesity treatment (surgical and lifestyle). PI: Ellen Schur, MD, MS

Currently Enrolling

Brain Effects on Appetite and Metabolism Study
This study examines if structural brain changes related to obesity play a role in the central regulation of appetite and weight gain in children. PI: Ellen Schur, MD, MS

Currently Enrolling

Lipid MRI Study: APOE Genotype Effects on Triglycerides and Blood Flow in the Human Brain

The purpose of this study is to enroll older adults to assess whether the E4 status affects change in global cerebral blood flow in response to a high fat drink. PI: Angela Hanson, MD

Currently Enrolling

ADT Study: Effect of Androgen Deprivation Therapy on Hypothalamic Gliosis in Men

The purpose of this study is to better understand why androgen deprivation therapy (ADT) increases risk of body weight gain, insulin resistance, and type 2 diabetes in men with prostate cancer. PI: Katya Rubinow, MD

Coming Soon

The Insulin-Only Bionic Pancreas Pivotal Trial

This randomized control trial will compare efficacy and safety endpoints using the insulin-only configuration of the iLet Bionic Pancreas System versus Usual Care during a 13-week study period. PI: Irl Hirsch, MD

Currently Enrolling

DERMIS: Defining, Reviewing, and Monitoring Skin Pathologies in T1D

This is an observatory study for people with type 1 diabetes mellitus who are using an insulin pump. DERMIS is an investigational study looking to answer the questions of why pump wearers’ skin changes after a number of years. PI: Irl Hirsch, MD

Coming Soon

Evaluating the Safety and Effectiveness of the Omnipod Horizon Automated Glucose Control System in Patients with Type 1 Diabetes

This study aims to evaluate the safety and effectiveness of the Omnipod Horizon Automated Glucose Control System. PI: Irl Hirsch, MD

Currently Enrolling

A Study on the Use of Real-Time Continuous Glucose Monitoring in Gestational Diabetes

The purpose of this study is to examine whether real-time continuous glucose monitoring improves glucose control, maternal outcomes, and fetal outcomes in patients diagnosed with gestational diabetes. PI: Nicole Ehrhardt, MD

Currently Enrolling

HDL Structure, Function and Glycemic Control in Diabetes

This study aims to learn about the differences in the structure of human lipoproteins (molecules in blood that transport fatty substances through the body) in people with and without diabetes and how these differences are related to blood sugar control. PI: Yi He, PhD & Irl Hirsch, MD

Coming Soon

Association between Retinal Angiography Findings and Kidney Histopathology in Participants with Diabetes

The purpose of this study is to learn about the relationship between eye disease and kidney disease in people with diabetes. The study aims to identify features of eye health that relate to how diabetes is affecting the kidney. PI: Christine Limonte, MD and Ian de Boer, MD MS

Coming Soon

Gliding Study

The main purpose of this study is to see if the participants switching with a bridging dose of insulin glargine to insulin degludec have less low blood sugars and better blood sugar control vs those who switch with no bridging dose. PI: Arthi Thirumalai, MBBS, Jing Chao, MD, Irl Hirsch, MD

Currently Enrolling

Completed Studies

BIGR: Brain Inflammation and Glucose Regulation The purpose of this study is to learn more about the differences in brain structure in people with and without Type 2 Diabetes and if these differences impact regulation of blood sugar over time. PI: Ellen Schur, MD, MS

Enrollment Complete

ONSET -9 Study

This study is to compare how well 2 medicines work and how safe they are in people with type 2 diabetes: 1) fast-acting insulin aspart (a new medicine) and 2) NovoLog® (a medicine doctors can already prescribe). PI: Subbulaxmi Trikudanathan, MD

Enrollment Complete

Medtronic Closed Loop Study

The purpose of this study is to evaluate the safety and effectiveness of the Hybrid Closed Loop system (HCL), which is built into the 670G insulin pump, in adult and pediatric patients with type 1 diabetes in a home setting. PI: Irl Hirsch, MD

Enrollment Complete

SOTA-CKD3 Study

The primary purpose of this study is to determine whether sotagliflozin taken orally once daily lowers hemoglobin A1C better than for the treatment of Type 2 diabetes in patients with moderate kidney problems. PI: Subbulaxmi Trikudanathan, MD

Enrollment Complete

Contact Us

UW Medicine Diabetes Institute

Clinical Research Unit

750 Republican St. Box 358062

Seattle, WA 98109

Nurse Manager: Elaine Adams, RN

The UWMDI CRU is located on the 3rd floor of the new UW Medicine South Lake Union F Bldg. adjacent to the UW Diabetes Institute Clinic