Dedicated to understanding the cellular and molecular mechanisms of diabetes-accelerated cardiovascular disease.
The Bornfeldt laboratory is dedicated to understanding the cellular and molecular mechanisms of diabetes-accelerated cardiovascular disease, so that these complications can be effectively treated or prevented.
People with type 1 or type 2 diabetes have a greater risk of developing cardiovascular disease (myocardial infarction, stroke, and peripheral cardiovascular disease, which can with time lead to the necessity to amputate limbs) caused in large part by atherosclerosis. These complications can also develop earlier in life than in people without diabetes. Risk factors for cardiovascular disease associated with diabetes include sub-optimal metabolic control, increased inflammation, and lipid abnormalities, such as increased levels of triglycerides and changed levels of HDL (“the good cholesterol”).
We also study blood samples from human subjects with diabetes to identify new biomarkers and mechanisms for cardiovascular disease risk in combination with mechanistic mouse models to identify new targets for prevention and treatment of cardiovascular complications of diabetes.
Our work is, or has been, funded by the National Heart, Lung, and Blood Institute, the National Institute of Diabetes and Digestive and Kidney Diseases, the American Heart Association, the American Diabetes Association, the Juvenile Diabetes Research Foundation, and Novo Nordisk A/S.
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Current Laboratory Members
Karin Bornfeldt, PhD
Principal Investigator, Edwin L. Bierman Professor of Medicine
Professor of Laboratory Medicine and Pathology
Farah Kramer, BS
Research Scientist II, Lab Manager
Research Interests: Developing and maintaining mouse models of diabetes-accelerated atherosclerosis (Bornfeldt et al. Am J Pathol. 2018).
Shelley Barnhart, BS
Research Scientist II
Research Interests: The role of the enzyme acyl-CoA synthetase 1 in myeloid cells in diabetes and other autoinflammatory diseases, and analysis of atherosclerotic lesion morphology (Basu et al. Circ Res. 2018).
Jenny Kanter, PhD
Research Assistant Professor
Research Interests: Effects of diabetes and insulin resistance on monocytes and macrophages in mouse models of diabetes-accelerated atherosclerosis, and mechanisms of diabetes-accelerated atherosclerosis (Kanter et al. 2018)
Brian Van Yserloo, BS
Research Scientist II
Research Interests: Research Scientist Research Interests: CRISPR/Cas9-mediated genome editing in cells and mice (Shimizu-Albergine et al. Proc Natl Acad Sci USA. 2016).
Jingjing Tang, PhD
Research Interests: The role of the protease ADAM17 in inflammation, macrophage proliferation, and atherosclerosis.
Luz Wigzell, BS
Research Interests: Histology and atherosclerosis lesion morphology.
Masami Shimizu-Albergine, PhD
Research ScientistResearch Interests: Cholesterol sensing through SCAP (Shimizu-Albergine et al. Proc Natl Acad Sci USA. 2016) and effects of triglyceride-lowering on atherosclerosis in the presence of diabetes.
Vishal Kothari, PhD
Research Interests:Analysis of HDL function and dysfunction in the setting of diabetes (He et al. Arterioscler Thromb Vasc Biol. 2018).
Hye Seung Jung, MD
Visiting Scientist from Seoul National University Hospital, Korea
Research Interests: The role of the acyl-CoA synthetase 3 in human endothelial cells.
Yunosuke Matsuura, MD, PhD
Research Interests: How diabetes affects the metabolism of macrophages.
Eyal Kedar, MD
Research Interests: Effects of lupus on monocyte and macrophage activation and atherosclerosis.
Tomohiro Nishizawa, PhD
Visiting Scientist from Daiichi-Sankyo Co., Japan
Research Interests: Effects of glucose in myeloid cells and atherosclerosis. Recent publications: Nishizawa & Bornfeldt 2012; Nishizawa et al. 2014
Sara Vallerie, PhD
Research Interests: Downstream effects of acyl-CoA synthetase 1 deficiency in macrophages as they relate to atherosclerosis.
Valerie Wall, BS
Graduate Student (Pathology Graduate Program
Research Interests: Acyl-CoA thioesterases in macrophage biology and atherosclerosis, glucose effects in smooth muscle cells.
UW Medicine Diabetes Institute
750 Republican Street, Box 358062
Seattle, WA 98109
Karin Bornfeldt: (206) 543-1681
Lab Main Line: (206) 616-3551
Fax: (206) 543-3567
To inquire about Postdoctoral and Graduate Student Openings click on: firstname.lastname@example.org