The Scarlett laboratory investigates integrated mechanisms whereby the brain and periphery regulate glucose and energy homeostasis.
The Scarlett laboratory investigates the integrated mechanisms whereby the brain and periphery regulation glucose and energy homeostasis and identifying how defects in this system contribute to diabetes and obesity pathogenesis. Recent work in the field of diabetes research supports the concept of a brain-centered glucoregulatory system that works cooperatively with the pancreatic islets, liver and intestines to regulate blood glucose. The current focus of the lab centers on the recently reported finding that the brain is a target for the fibroblast growth factor (FGF), FGF1, and that in response to central FGF1 administration that the brain can promote sustained glucose lowering in murine models of obesity and diabetes. Specifically, our current studies are focused on elucidating the specific central neurocircuits, receptors and intracellular signaling pathways that are targeted by central FGF1 therapy. A second set of studies examines the peripheral mechanisms that underlie the glucose-lowering effect of brain FGF1 signaling, specifically focusing on mechanisms whereby basal glucose clearance is increased due to increased hepatic glucose uptake and pancreatic islet function. A final line of research relates to integrins, which, although recently implicated in the control of insulin sensitivity in peripheral tissues, have not previously been a focus of studies investigating brain control of glucose homeostasis. Ultimately, the overarching goal of this research is to achieve an improved understanding of the central and peripheral mechanisms that control glucose and energy homeostasis to support the development of new, more effective treatment options for diabetes and obesity.
Members of the Laboratory
Bao Anh Phan
Research ScientistBao Anh Phan recently joined the laboratory in 2017. She completed a Bachelor of Science in Biochemistry at the University of Washington. She is an expert in histology, with the performance of cryostat sectioning, immunohistochemical staining and western blot analysis.
Research ScientistTrista has a Master of Animal Science degree from the University of Melbourne and has worked in the laboratory since 2016. She is our Animal Studies Coordinator and is responsible for rodent metabolic phenotyping studies including central and peripheral injections and measures of energy and glucose homeostasis.
UW Medicine Diabetes Institute
750 Republican Street, Box 358062
Seattle, WA 98109
Office: (206) 897-5282
Lab: (206) 897-5280
For information on postdoctoral and graduate student openings, contact: Jarrad.Scarlett@seattlechildrens.org