Dr. John Douglass, PhD, is first author and Dr. Joshua Thaler, MD, PhD is senior author on the article entitled “Astrocyte IKKβ/NF-κB signaling is required for diet-induced obesity and hypothalamic inflammation”, in press at Molecular Metabolism. The article reports the the first direct evidence that astrocyte-mediated inflammation promotes susceptibility to weight gain from high-fat diet feeding, suggesting a nonneuronal CNS cellular target for obesity therapeutics.