Atypical PKC paper published in Diabetes

Atypical PKC paper published in Diabetes

Dr. Mauricio Dorfman, PhD, is first author and Dr. Joshua Thaler, MD, PhD is senior author on the article entitled “Deletion of Protein Kinase C Lambda in POMC Neurons Predisposes to Diet-Induced Obesity”, published in the January 2017 issue of Diabetes. The article reports that reduced signaling by atypical protein kinase C lambda in POMC neurons lowers leptin responsiveness and melanocortin content, resulting in increased predisposition to diet-induced obesity. Other UW Diabetes Institute investigators co-authoring the paper include Gregory Morton, PhD and Michael Schwartz, MD.