Dr. Michael Schwartz has been awarded a 4-year NIH R01 for his project ” Novel Brain Mechanisms Controlling Glucose Homeostasis”. This project is based upon recently published evidence from the Schwartz Laboratory that the brain can rapidly, potently and selectively increase insulin-independent glucose lowering. The overarching goals are to employ state-of-the-art methods of metabolic analysis in defined mouse models to 1) more clarify how these centrally mediated effects are mediated and identify the humoral signals that activate them, 2) delineate peripheral mechanisms of glucose lowering, and 3) establish their physiological relevance. Dr. Schwartz is the RH Williams Endowed Chair in Medicine, Division of Metabolism, Endocrinology and Nutrition.