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WAVE T1D

A Randomized Phase 1/2 Trial of Low Dose Anti-thymocyte Globulin (ATG) with Subsequent Adalimumab or Verapamil in New Onset Type 1 Diabetes (WAVE T1D)

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Study Description

IRB #

STUDY00005466

NCT #

NCT07061574

Principal Investigator

Petter Bjornstad, MD

Study Location

Seattle Children’s Hospital

This study is being done in people with newly diagnosed Type 1 Diabetes (T1D). We want to see if using a treatment called Anti-thymocyte Globulin (ATG), followed by either Adalimumab or Verapamil, can help people keep making insulin for a longer time which may also help to control blood glucose. Those that enroll will be in the study for up to 3 years. Over the 3 years there will be around 12 office visits and at least 6 scheduled phone contacts which will include:

  •  2 IV infusions of ATG
  • Biweekly under-the-skin (subcutaneous) injections every other week (adalimumab or placebo) OR taking a daily pill (verapamil or placebo)
  • Wear a Continuous Glucose Monitor (CGM)
  • Physical Exams
  • Electrocardiograms (ECGs) (to check how your heart beats)
  • Have blood drawn for lab tests
  • Daily Insulin Recording
  • Mixed Meal Tolerance Test (MMTT) (to see how well your pancreas makes insulin)

More at clinicaltrials.gov

FAQ Title

Learn more about  how you can contribute to important research by volunteering for WAVE T1D

Who Can Participate?
  • Have been recently diagnosed with T1D and can start the treatment phase within 6 months of diagnosis
  • Be at least 9 years old and less than 21 years old
  • Weigh more than 66lbs
  • Use only insulin to control blood sugar (no other glucose-lowering medicines).
  • Are up-to-date on recommended vaccines for your age and willing to avoid
Compensation Provided

Participants will be compensated per visit, ATG infusion, and MMTT.

If you complete all study visits in the main study with extended treatment phase (3 years), you may be paid up to $2,300.00.

Contact Study Team

Interested? 👉 Click here to contact the study team <<Link will open an email directed to

amelia.johnson3@seattlechildrens.org>>

Contact Name: Amelia Johnson

Phone Number: (206) 884-7865

Email: amelia.johnson3@seattlechildrens.org

Contact the Study Team - WAVE T1D

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