Dr. Joshua Thaler is senior author on a publication in Cell Metabolism entitled “Obesity-associated microglial inflammatory activation paradoxically improves glucose tolerance” which is featured as a Research Highlight in Nature Reviews Endocrinology entitled “Microglial inflammatory signalling improves glucose tolerance”. This paper reports on recent findings that contrary to expectation, microglial activation and inflammatory signaling improves glucose tolerance despite promoting weight gain. This occurs via altered hypothalamic glucose sensing, which ultimately increases insulin secretion via a parasympathetic pathway. Dr. Thaler is an Associate Professor of Medicine, Division of Metabolism, Endocrinology and Nutrition. UWMDI Co-authors include Mauricio Dorfman, PhD and Kelly Ness, PhD.
Full Publication – Cell Metabolism : https://doi.org/10.1016/j.cmet.2023.07.008
Research Highlight feature in Nature Reviews Endocrinology: https://www.nature.com/articles/s41574-023-00892-7