Dedicated to understanding the impact of fatty acids and inflammatory mediators on adipocyte biology during the development of obesity and subsequent weight loss.
The prevalence of obesity and associated diseases such as type 2 diabetes is rapidly reaching epidemic proportions. Representing major cellular constituents of adipose tissue, adipocytes and macrophages are regarded as prominent players in the metabolic, hormonal, and homeostatic regulation of adiposity. Despite the fundamental role adipose tissue plays in whole body metabolism, nutritive mechanisms that contribute to its maintenance in the context of obesity remain poorly understood. Dr. den Hartigh’s research focuses on the effects of nutrient excess on cellular metabolism, with particular attention given to the effects of fatty acids on cell types associated with the development of obesity such as adipocytes and monocytes/macrophages.
Inflammation of visceral adipose tissue is thought to be associated with insulin resistance, systemic inflammation and atherosclerosis. Furthermore, adipose tissue inflammation is characterized by immune cell accumulation, with macrophages as the predominant infiltrating cell type. We are particularly interested in the role of excess nutrients derived from glucose, as well as long- and short-chain fatty acids on adipose tissue inflammation and metabolism. We use in vitro systems and mouse models to study how obesity derived by nutrient excess leads to adipose tissue and systemic inflammation.
Current and Recent Lab Members
Laura den Hartigh, PhD
UW Medicine Diabetes Institute
750 Republican Street, Box 358062
Seattle, WA 98109
Laura den Hartigh: (206) 543-8406
Laboratory: (206) 543-2264
Fax: (206) 543-3567
Laura den Hartigh: firstname.lastname@example.org
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